Transplant Center

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Jean  F.  Botha  MB, BCh, FCS

  • Alan Langnas

    Director of Hepatobiliary Surgery, Director Living Donor Liver Transplant Program, Section of Transplantation

  • Appointment:

    Associate Professor of Surgery, Transplant Surgeon, University of Nebraska Medical Center

  • Credentials:

    MB, BCh: Doctor of Medicine, University of the Witwatersrand, Johannesburg, South Africa

    Fellowship: Solid Organ Transplantation, University of Nebraska Medical Center

    Residency: General Surgery, University of the Witwatersrand, Johannesburg, South Africa
       

  • Phone: 402-559-5000

    Fax: 402-559-3434

  • Bio:

    Dr. Jean Botha, MB, BCh, FCS(SA), is Director of Hepatobiliary Surgery and  Director of the Living Donor Liver Transplant Program.  He is an Associate Professor of Surgery in the Section of Transplantation.  He has been a member of the liver transplant team since 2000. He received his medical degree and completed his general surgical residency from the University of the Witwatersrand in Johannesburg, South Africa.  He earned a fellowship in Solid Organ Transplantation from the University of Nebraska Medical Center. He was a transplant surgeon at the University of the Witwatersrand Organ Transplant Program in Johannesburg, South Africa.

  • Awards and Honors:

    Young Investigator Award, American Transplant Congress. Presented at the Third Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation. Washington, DC, April 2002.

    Kendall, Sherwood, Davis and Geck Surgical Research Award (1999).

    The Novartis Young Investigators Award for the Best Paper by a Young Investigator at the 18th Meeting of the Southern African Transplantation Society (1999).

    Kendall, Sherwood, Davis and Geck Surgical Research Award (1998)

    The Astra Prize for Excellence in Surgery, Department of Surgery, University of Cape Town (1998).

    The Bunny Angorn Prize for the Best Paper Presented at the Surgical Research Society of South Africa Meeting (1998).

    The Association of Surgeons of South Africa Travelling Fellowship Award. (1998).

    The Michael and Janie Miller Prize for the Best Resident in the Department of Surgery University of the Witwatersrand (1997).

    The Bunny Angorn Prize for the Best Paper Presented at the Surgical research Society of South Africa Meeting (1996).

    The Douglas Medal for the Most Outstanding Performance in the Fellowship of the College of Surgeons Final Examination (1996).

    The AE Wilkinson Medal for the Most Distinguished Student in the Clinical Part of the Final Surgery Examination (1990).

    The Jack Baynash prize in Medicine for the Best Student in Internal Medicine in the Fourth and Fifth Years of study at Medical School (1989).

  • Research:

    Integrated Therapeutics        Mukherjee (PI)        2006-Present
    P04590
    PROTECT- Pegylated Interferon Alfa-2B and Ribavirin after Orthotopic Liver Transplantation: Efficacy and Safety in Hepatitis C Recurrence Therapy
    The major goal of this research study is to evaluate the effectiveness and safety of Pegylated interferon alfa-2b in combination with ribavirin in patients whose hepatitis c virus has recurred after liver transplantation.
    Role:  Co-Investigator

    Novartis Pharmaceuticals Corp    Mukherjee (PI)        2006-Present
    COLO400A2426
    A Multicenter, Randomized, Open Label Study to Compare the Development of Liver Fibrosis at 12 Months After Transplantation for Hepatitis C Cirrhosis in Patients Receiving either Neoral or Tacrolimus
    The major goal of this research study is to see if the time to recurrence of liver fibrosis is longer with Neoral than Tacrolimus.
    Role:  Co-Investigator

    NIH/NIDDK            Langnas (PI)        2005-Present
    R01 HD045694
    Functional Outcomes in Pediatric Liver Transplantation
    The major goal of this project is to compare health-related quality of life of children who have had liver transplants to that of children in the general population.
    Role:  Co-Investigator

    NIH/NIDDK
    5U01DK061693-02            Langnas (PI)            2004-Present               
    SPLIT (Studies of Pediatric Liver Transplantation), A Multicenter, Prospective Study to Collect Scientific Data on Pediatric Liver Transplantation
    The major goal of this research is designed to characterize and follow trends and indications for transplant, transplant techniques, and outcomes of pediatric isolated liver transplant recipients into one registry.
    Role:  Co-Investigator

    Novartis Pharmaceuticals        Langnas (PI)            2004-Present
    RAD001A 2401
    A Facilitated Access Program to Provide Everolimus (RAD) for Maintenance Patients Completing Therapy in RAD Trials in Solid Organ Transplantation
    The major goal of this research is to continue to monitor long-term safety and efficacy of Everolimus in recipients of solid organ transplants.
    Role:  Co-Investigator

    Wyeth Research             Grant (PI)            2002-Present
    0468H1-313       
    A Randomized, Open-Label, Comparative Evaluation of Conversion from Calcineurin Inhibitor (CI) Treatment to Sirolimus Treatment versus Continued Calcineurin Inhibitor Treatment in Liver Allograft Recipients Undergoing Maintenance Therapy
    The major goal of this research is to determine whether kidney function can be protected through the use of Sirolimus maintenance therapy alone without increasing the risk of rejection.
    Role: Co-Investigator

    Completed Research Support (within 3 years)
    Genzyme Corporation        Langnas (PI)            2005-2008
    THYMO102700103               
    A Randomized, Controlled, Multicenter Study of Thymoglobulin Induction Therapy with a Calcineurin Inhibitor Sparing Regimen in Liver Transplant Patients
    The major goal of this research study is explore the safety and efficacy of Thymoglobulin induction therapy in liver transplant patients with renal dysfunction.
    Role:  Co-Investigator

    CellzDirect                Fox (PI)            2004-2006                   
    Hepatic Research Registry
    Isolation of Human Liver Cells for Research and Establishment of a Hepatic Research Registry
    The major goal of this research is to obtain excess liver tissue following liver resection for various liver research projects. 
    Role: Co-investigator

    XTL Biopharmaceuticals        Mukherjee (PI)        2004-2006                 
    2003-12
    A Phase II, Multicenter, Randomized, Open-Label, Dose-Ranging, Parallel Group Study of the Anti-Viral Effects, Pharmacokinetics and Safety of Hepex-B as Compared to Hepatitis B Immune Globulin in Patients who have Received Hepatic Allografts for Treatment of End-Stage Liver Disease due to Hepatitis B Virus Infection.
    The major goal of this project is to compare the anti-viral effects of Hepex-B and Hepatitis B Immune Globulin.
    Role: Co-Investigator

  • Publications, Most Recent:

    Botha JF, Campos BD.  Salvage transplantation:  does saving livers save lives?  American Journal of Transplantation 2008; 8: 1085-1086.

    Repeat surgical bowel lengthening with the STEP procedure.
    Andres AM, Thompson J, Grant W, Botha J, Sunderman B, Antonson D, Langnas A, Sudan D.
    Transplantation. 2008 May 15;85(9):1294-9.
    PMID: 18475187 [PubMed - indexed for MEDLINE]

    Comparison of intestinal lengthening procedures for patients with short bowel syndrome.
    Sudan D, Thompson J, Botha J, Grant W, Antonson D, Raynor S, Langnas A.
    Ann Surg. 2007 Oct;246(4):593-601; discussion 601-4.
    PMID: 17893496 [PubMed - indexed for MEDLINE]

    Role of an intestinal rehabilitation program in the treatment of advanced intestinal failure.

    Torres C, Sudan D, Vanderhoof J, Grant W, Botha J, Raynor S, Langnas A.,
    J Pediatr Gastroenterol Nutr. 2007 Aug;45(2):204-12.
    PMID: 17667717 [PubMed - indexed for MEDLINE]

    Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation.
    Botha JF, Thompson E, Gilroy R, Grant WJ, Mukherjee S, Lyden ER, Fox IJ, Sudan DL, Shaw BW Jr, Langnas AN.
    Liver Int. 2007 Aug;27(6):758-63.
    PMID: 17617118 [PubMed - indexed for MEDLINE]

    Botha JF, Langnas, AN.  Liver transplantation for hepatocellular carcinoma:  An Update.  Journal of the National Comprehensive Cancer Network.2006 Sept.;4(8)

    Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome.
    Botha JF, Grant WJ, Torres C, Iverson AK, Sudan DL, Shaw BW Jr, Langnas AN.
    Liver Transpl. 2006 Jul;12(7):1062-6.
    PMID: 16710856 [PubMed - indexed for MEDLINE]
     
    Botha JF, Horslen, SP.  Small bowel transplantation:  Literature review 2003-2005. Pediatr Transplant.2006 Feb;10(1):7-16
    Grant W, Botha JF.  Surgical techniques for liver/small bowel and isolated bowel transplants.  Current Opinion in Organ Transplantation 2005, 10:142-146.
    Sudan, D, DiBaise J, Torres C, Thompson J, Raynor S, Gilroy R, Horslen S, Grant W, Botha J, Langnas A.  A multidisiplinary approach to the treatment of   intestinal failure. Journal of Gastrointestinal Surgery. 2005; 9(2): 165-175.

  • Presentations:

    1.    Merits of a more individualized assessment of which organs to transplant into patients – debate.  Presented at 2008 SPLIT Annual Meeting, St. Louis, MO, October 16, 2008.
    2.    Living liver donation with small-for-size grafts.  Presented at Wits Donald Gordon Medical Centre, Johannesburg, South Africa, October 1, 2008.
    3.    Living liver donation with small-for-size grafts.  Presented at the University of Nebraska Medical Center Optum Health Care Solutions, July 22, 2008.
    4.    Living donor liver transplantation.  Presented at Digestive Disease Week 2008, San Diego, CA, May 19, 2008.
    5.    Adult-to-adult living donor liver transplantation using left lateral segment grafts.  Presented at the University of Nebraska Medical Center Department of Surgery Grand Rounds, January 9, 2008.
    6.    Adult-to-adult living donor liver transplantation using left lateral segment grafts.  Presented at Grand Rounds at the University of Virginia, Charlottesville, Viriginia.  December 2007.
    7.    Pancreatic cancer surgery presented at 8th Annual Advances in Oncology Symposium, Topeka, KS. September 21, 2006
    8.    International Liver Transplant Society Congress, Milan, Italy. Hepatitis C virus (HCV) fibrosis progression following liver transplantation:  Impact of donor steatosis.  April 30-May7, 2006.
    9.    Hepatocellular carcinoma:  medical and surgical management, presented at Surgical Grand Rounds, Iowa Methodist Medical Center, Des Moines, IA. March 9, 2006
    10.    Taking the tension out of portal hypertension, presented at the University of Nebraska Medical Center Surgical Grand Rounds, Omaha, NE. February 15, 2006
    11.    Isolated liver transplantation in Short Bowel Syndrome presented at International Liver Transplantation Society, Los Angeles, CA.  July 23, 2005.
    12.    Liver transplantation for hepatocellular carcinoma presented at Surgical Grand Rounds at the University of Iowa College of Medicine, Iowa City, IA.  April 22, 2005.
    13.    Isolated liver transplantation in Short Bowel Syndrome presented at the American Association for the Study of Liver Diseases – The American Transplant Congress, Seattle, WA.  May, 2005.